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KMID : 0941820040140010032
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Korean Journal of Clinical Pharmacy
2004 Volume.14 No. 1 p.32 ~ p.35
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Pharmacokinetics of Verapamil in Rabbits with Hepatic Disorder Induced by Carbon Tetrachloride
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Choi Jun-Shik
Kim Hyoung-Joong
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Abstract
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The purpose of this study was to investigate the pharmacokinetic changes of verapamil in rabbits with hepatic disorder induced by carbon tetrachloride. The plasma concentrations of verapamil were increased significantly (p<0.05, in slight group; P<0.01, in moderate and severe group) in all groups of hepatic disorder compared to the control group. Morover, the C_{max};in;slight;(77.9% increase), moderate (110% increase), and severe (174% increase) hepatic disorder groups were significantly (p<0.05, in slight; p<0.01, in moderate and severe) higher than that in control rabbits. These resulted in significantly (p<0.05, in slight; p<0.01, in moderate and severe) greater area under the plasma concentration-time curve (AUC) in moderate (49.8% increase), moderate (95.0% increase), and severe (144% increase) hepatic disorder groups than that in control rabbits. Hence, the relative bioavailability values were 149, 195, and 244% for slight, moderate, and severe hepatic disorder groups, respectively. This could be due to decrease in metabolism of verapamil in the liver because of suppressed hepatic function in the hepatic disorder groups because verapamil is mainly metabolized in the liver.
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KEYWORD
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Verapamil, Pharmacokinetics, Hepatic disorder, Carbon tetrachloride, Rabbits
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